Dr. Bradley Love is building a tool that can predict the future. Dr. Bradley Love is transforming neuroscience research with AI. He's the creator of BrainGPT, a large language model that can predict the results of neuroscience studies—before they’re conducted. And it performs better than human experts. We spent 90 minutes exploring how AI is reshaping scientific research and our understanding of the brain. Bradley argues that as scientific knowledge grows exponentially, we need new tools to make...
Jul 10, 2024•59 min•Ep. 26
Claire Vo built ChatPRD—an on-demand chief product officer powered by AI. It’s now used by over 10,000 product managers and is pulling in six figures in revenue. The best part? Claire has a demanding day job as the CPO at LaunchDarkly. So she built all of ChatPRD herself—over the weekend—with AI. I sat down with Claire to talk about how ChatPRD works, how she built it as a side hustle using AI, and all of the ways she’s using AI tools to accelerate her work and life. We get into: How she used AI...
Jun 20, 2024•1 hr 5 min•Ep. 25
An interview with best-selling sci-fi novelist Robin Sloan One of my favorite fiction writers, New York Times best-selling author Robin Sloan , just wrote the first novel I’ve seen that’s inspired by LLMs. The book is called Moonbound , and Robin originally wanted to write it with language models. He tried doing this in 2016 with a rudimentary model he built himself, and more recently with commercially available LLMs. Both times Robin found himself unsatisfied with the creative output generated ...
Jun 12, 2024•54 min•Ep. 24
We use it to find bestselling author Steven Berlin Johnson’s next project. I sat down with bestselling author Steven Johnson to see if we could come up with a concept for his next project—using AI. The results were amazing. We loaded 200,000 words of NASA transcripts and all of Steven’s reading notes since 1999 into NotebookLM, Google’s personalized research assistant. We wanted to see if it could help us explore the Apollo 1 fire and find relevant and surprising ideas from history that could wo...
Jun 06, 2024•56 min•Ep. 23
Learn how the smartest people in the world are using AI to think, create, and relate. Each week I interview founders, filmmakers, writers, investors, and others about how they use AI tools like ChatGPT, Claude, and Midjourney in their work and in their lives. We screen-share through their historical chats and then experiment with AI live on the show. Join us to discover how AI is changing how we think about our world—and ourselves. For more essays, interviews, and experiments at the forefront of...
May 29, 2024•2 min•Ep. 22
New York Times journalist Kevin Roose has 18 new friends —none of whom are human. Kevin formed a collection of “friends”—AI personas with distinct personalities and backstories—using apps like Kindroid and Nomi . Among these were fitness guru Jared, San Francisco-based therapist Peter, and pragmatic trial lawyer Anna. He talked to them every day for a month, sharing personal stories, seeking advice, and even asking for “fit” checks. And this wasn’t Kevin’s first unusual interaction with AI chara...
May 15, 2024•50 min•Ep. 21
Nick Dobos, maker of the #1 programming GPT, on prompt-gramming with AI You can go from having an idea to deploying a live website in minutes. All you have to do is prompt Grimoire , the number-one custom GPT for programming, with an image or even a single word about your idea. As you watch the LLM process your request, Grimoire works with a web host on the backend, and just minutes later, your website will be live on the internet. Grimoire, which has facilitated over 1 million chats, can help y...
May 01, 2024•57 min•Ep. 20
The future of AI technology isn’t just faster or more powerful—it’s empathetic. My guest for this episode, Alan Cowen, is leading the charge with the first-ever emotionally intelligent AI. Alan is the co-founder and CEO of Hume, an AI research laboratory developing models trained to identify and measure expressions of emotion from voice inflections and facial expressions. The best part? Once it understands these emotions, the AI is designed to interact with users in a way that optimizes for huma...
Apr 24, 2024•56 min•Ep. 19
Learn how to use philosophy to run your business more effectively Reid Hoffman thinks a masters in philosophy will help you run your business better than an MBA. Reid is the cofounder of LinkedIn, a partner at venture capital firm Greylock Partners , the host of the Masters of Scale podcast, and a prolific author . But before he did any of these things, Reid studied philosophy—and by helping him understand how to think, it made him a better entrepreneur. A good student of philosophy rigorously e...
Apr 17, 2024•1 hr 1 min•Ep. 18
Seth-Stephens Davidowitz wrote a book in 30 days—and he did it with ChatGPT. Seth is a data scientist, economist, and author who challenged himself to write a book—Who Makes the NBA?—in less than 1 month after realizing how fast he could work by using ChatGPT plugin Advanced Data Analysis. But along the way he discovered something else: Writing with AI wasn’t just faster, it was also way more fun. Seth outsourced the boring parts of data analysis—like cleaning data, merging files, and looking up...
Apr 10, 2024•1 hr 14 min•Ep. 17
Nicholas Thorne is building Squarespace for the AI age. It’s called Audos, and it’s an AI chatbot to help any entrepreneur go from idea to: - Pitch deck - Working website - Custom GPT - User interviews with real customers All in just a few minutes. And he did it using ChatGPTapp. It’s AI all the way down—and it’s one of the most impressive AI businesses I’ve ever seen. Nicholas is a general partner at Prehype, an incubator that launched Barkbox and Ro Health. It’s also where I started Every, so ...
Mar 27, 2024•1 hr 1 min•Ep. 16
Antidepressants changed my life. I have OCD and antidepressants did what nearly a decade of therapy, meditation, and supplements couldn’t: they allowed me to live my life without being in a 24/7 spiral. (Bonus: they actually made therapy and meditation far more helpful once they started to work.) I think antidepressants are seriously misunderstood. Yes, they blunt negative emotions . But they also operate on personality and sense of self: they can make you bolder, less sensitive to failure, and ...
Mar 20, 2024•1 hr 5 min•Ep. 15
You can build and run a one-person internet business that earns half a million in annual revenue—with AI. Ben Tossell showed me exactly how in this episode. Ben is the founder of Ben’s Bites—one of the best daily AI newsletters out there, which I love reading every day—and an investor in a number of promising early-stage AI startups. Ben is also an experienced founder whose no-code platform Makerpad was acquired by Zapier. I think Ben is really good at starting profitable internet businesses tha...
Mar 13, 2024•1 hr 16 min•Ep. 14
I made the greatest trade of my life with Jesse Beyroutey in 2019. We bought Nvidia shares when they were trading at $33. They’re worth nearly $800 today. I sat down with Jesse to top that trade in 90 minutes using Gemini Pro 1.5’s incredible 1 million token context window—and make a $1,000 trade live on the show. Jesse is a managing partner at IA Ventures, a $600 million venture fund with seed investments in companies like Wise and Digital Ocean. He’s also a very close friend and one of the sma...
Mar 01, 2024•1 hr 37 min•Ep. 13
You can break into Hollywood with a movie you made alone in your room without using a single camera. Dave Clark showed me how live on this show. Dave Clark is a film director and commercial director with experience working with brands like HP and Intel who is now experimenting with cutting-edge AI technology. He recently produced a popular sci-fi short Borrowing Time , which has over 110,000 views on X and was mentioned in Forbes . Dave made this film only using AI tools like Midjourney, text-to...
Feb 28, 2024•1 hr 5 min•Ep. 12
Are you a curious person with a lot of ideas and little time? Anne-Laure Le Cunff can show you how to do it all. Anne-Laure is the founder of one of my favorite internet communities for curious minds, Ness Labs, a prolific writer, and a neuroscience PhD candidate. She’s also writing a book, Liminal Minds, that’ll be out later this year. And she said that the reason she can run a business, write a book, and do a PhD all at the same time is ChatGPT. Anne-Laure is one of the busiest people I know, ...
Feb 21, 2024•1 hr 29 min•Ep. 11
The next big idea is hiding in plain sight. It’s right here, scattered across the internet in incoherent fragments. Steph Smith, my guest for this episode, knows how to connect the dots. Steph Smith is a prolific online creator, host of the a16Z podcast , author of a book about building a successful blog called Doing Content Right , and creator of Internet Pipes , a toolkit to surface useful insights on the internet. I sat down with Steph to explore the internet through her eyes. I discover the ...
Feb 14, 2024•1 hr 59 min•Ep. 10
You can make a video game without writing a single line of code. Logan Kilpatrick uses ChatGPT to show me how. Logan is OpenAI’s first developer relations and advocacy hire. A big part of Logan’s job is supporting the community of builders using ChatGPT, DALL-E, and the OpenAI API. He’s also deeply invested in growing this community, convinced that AI tools can enable more people to build. To prove this point, Logan and I build a video game live on the show. We use GPT Builder and ChatGPT to cre...
Feb 07, 2024•1 hr 45 min•Ep. 9
Dr. Gena Gorlin (https://twitter.com/Gena_I_Gorlin ) is a clinical psychologist at UT Austin whose goal is to raise the ceiling on human potential. I sat down with her to discuss how ChatGPT has become a key tool in her quest for radical self-betterment. In this episode, she feeds ChatGPT a list of her old journal entries, and it conducts the most thorough and insightful annual review and goal-setting session you’ve ever seen. We watch as ChatGPT writes a year-by-year personal biography of her l...
Jan 31, 2024•1 hr 23 min•Ep. 8
Tyler Cowen is an economist who has been thinking about the impact of technology on life, work, and the economy for the past decade. He is a prolific writer behind the leading economic blog Marginal Revolution , a professor of economics at George Mason University, and the author of 17 books. In this episode, I dive deep with him on how ChatGPT will change the economy, and how he uses it in his own life. We explore Tyler’s predictions about how AI will impact the economy, distilling decades of co...
Jan 24, 2024•1 hr 7 min•Ep. 7
David Perell is one of the best known internet writers of his generation. He’s amassed almost a half million followers on X, hosts the popular podcast How I Write , and founded Write of Passage , which has taught thousands of students how to be digital writers. We go deep on using ChatGPT to: Doing deep reading of old books Finding anecdotes that spread Better understanding your taste Finding your heroes Understanding your blind spots as a leader Unpacking the strategy of your business If you fo...
Jan 18, 2024•1 hr 27 min•Ep. 6
This show might be a first in the history of podcasts: Researcher Geoffrey Litt and I built an app together using ChatGPTapp and Replit in under 60 minutes—while we talked. We wanted to show how AI and ChatGPT change who gets to build software and how they usher in a world where everyone can modify and remix the apps they use every day. So we did it live, and ChatGPT delivered a working prototype at the end of the episode. It was a tiny glimpse of the future—and it pushes the boundaries of...
Jan 10, 2024•1 hr 5 min•Ep. 5
Sometimes ChatGPT is a copilot, sitting beside you, taking directions, and guiding you as you fly through your work. At other times, it’s a subordinate. It’s not just an assistant or a companion, but a trusted deputy, someone—or something—that’ll heed instructions and complete tasks. This is how our guest, Nathan Labenz, thinks about ChatGPT. In this episode, Labenz—the founder of the AI video company Waymark and the host of his own podcast called The Cognitive Revolution —uses ChatGPT to write ...
Dec 20, 2023•1 hr 13 min•Ep. 4
TL;DR: Today we’re releasing a new episode of our podcast How Do You Use ChatGPT? I go in-depth with Notion research engineer Linus Lee on how he uses ChatGPT and Notion AI to maximize creative control. Watch on X, YouTube, or Spotify. You might think that being an AI researcher would mostly involve solving complicated programming problems and thinking through mathematical equations. Instead, a big part of the job is rewriting parts of your prompts in ALL CAPS in order to make sure the AI model ...
Dec 13, 2023•1 hr 14 min•Ep. 3
How Nat Eliason uses ChatGPT to write books: Nat Eliason is a shape-shifter. He’s a writer with a book deal from Random House, a crypto trader, a Roam Research aficionado, a marketer, a book podcaster, a parent, and a seed oil iconoclast. He's amassed thousands of newsletter subscribers, 70,000 followers on X, and 110,000 on TikTok. His secret weapon for all of his exploring? ChatGPT. Nat took me through why he uses it every day for his work and his life. In this interview we talk about using Ch...
Dec 01, 2023•41 min•Ep. 2
About the show I believe that ChatGPT is the most important creative tool of the decade. I think it can help us write better , create art, efficiently ship products , build great businesses, make smart decisions , and even learn something about ourselves ,. But it’s still so early. Most of us don’t even really know how to use ChatGPT. We have a feeling that it’s powerful, interesting, and important—but we haven’t figured out how to incorporate it into our lives. There are a few people, though, w...
Nov 15, 2023•47 min•Ep. 1
