The web is unhealthy, and AI agents are about to rewrite how we shop. In this episode, a16z General Partner Alex Rampell and Partner Justine Moore explore how AI agents will change commerce and the implications for Google’s business model, affiliate marketing, online shopping, and more. Timecodes: 0:00 Introduction 0:12 The Role of AI Agents in Commerce 1:28 Affiliate Marketing & Impulse Buys 4:02 Observing Consumer Behavior & AI 6:08 Dynamic Pricing & E-commerce Trends 7:20 Online v...
Sep 17, 2025•45 min•Ep. 927
OpenAI’s Codex has already shipped hundreds of thousands of pull requests in its first month. But what is it really, and how will coding agents change the future of software? In this episode, General Partner Anjney Midha goes behind the scenes with one of Codex’s product leads- Alexander Embiricos - to unpack its origin story, why its PR success rate is so high, the safety challenges of autonomous agents, and what this all means for developers, students, and the future of coding. Timecodes: 0:00...
Sep 16, 2025•1 hr 20 min•Ep. 926
Can we make science as fast as software? In this episode, Erik Torenberg talks with Patrick Hsu (cofounder of Arc Institute) and a16z general partner Jorge Conde about Arc’s “virtual cells” moonshot, which uses foundation models to simulate biology and guide experiments. They discuss why research is slow, what an AlphaFold-style moment for cell biology could look like, and how AI might improve drug discovery. The conversation also covers hype versus substance in AI for biology, clinical bottlene...
Sep 15, 2025•56 min•Ep. 925
In this conversation from Lenny’s Podcast, Ben Horowitz joins Lenny to discuss the psychological muscle every founder needs, why hesitation can be fatal for CEOs, when it’s time to replace a founder, and how to normalize failure while building confidence. They also explore the Databricks founding story, investing in Adam Neumann after WeWork, whether AI is in a bubble, where the real opportunities lie, and Ben’s work with the Paid in Full Foundation supporting hip-hop pioneers. The result is a c...
Sep 12, 2025•1 hr 36 min•Ep. 924
The $13T U.S. mortgage market serves 50M homeowners but still runs on decades-old software. In this episode, a16z GP Angela Strange hosts Tim Mayopoulos (ex-CEO of Fannie Mae and ex-president of Blend), Mike Yu (co-founder and CEO of Vesta), and Andrew Wang (co-founder and CEO of Valon) to unpack why standardization and regulation slow change, and how modern loan-origination and servicing platforms, cleaner data, and AI can cut costs, boost transparency, and reduce errors. They also discuss poli...
Sep 11, 2025•55 min•Ep. 923
Why do some consumer products explode into networks that reshape the internet, while others fade away? Today on the podcast, a16z general partners Anish Acharya and Chris Dixon take on that question. Anish invests in AI-native consumer products and the next wave of consumer tech. Chris is best known for his work in Web3 and network economies, and he’s also led some of a16z’s biggest consumer bets. Together, they cover the history and power of consumer networks, the exponential forces that shape ...
Sep 10, 2025•43 min•Ep. 916
What happens when AI collides with salesmanship, streaming-era sports, and healthcare? In this episode, Erik Torenberg is joined by Mark Cuban, entrepreneur, Dallas Mavericks co-owner, and founder of Cost Plus Drugs. Topics include fiery group chats and how dissent sharpens thinking, the sales playbook of modern politics, and concrete fixes for U.S. healthcare like ending PBM opacity, publishing real prices, and government-backed patient financing. Mark also explains how AI is pushing media from...
Sep 09, 2025•1 hr 1 min•Ep. 922
Who’s speaking up for startups in Washington, D.C.? In this episode, Matt Perault (Head of AI Policy, a16z) and Collin McCune (Head of Government Affairs, a16z) unpack the “Little Tech Agenda” for AI- why AI rules should regulate harmful use, not model development; how to keep open source open; the roles of the federal government vs states in regulating AI; and how the U.S. can compete globally without shutting out new founders. Timecodes: 0:00 – Introduction 1:12 – Defining the Little Tech Agen...
Sep 08, 2025•57 min•Ep. 921
Stainless founder Alex Rattray joins a16z partner Jennifer Li to talk about the future of APIs, SDKs, and the rise of MCP (Model Context Protocol). Drawing on his experience at Stripe—where he helped redesign API docs and built code-generation systems—Alex explains why the SDK is the API for most developers, and why high-quality, idiomatic libraries are essential not just for humans, but now for AI agents as well. They dive into: The evolution of SDK generation and lessons from building at scale...
Sep 06, 2025•27 min•Ep. 919
Taken from The Oprah Podcast, this special episode brings together Shaka Senghor, a16z cofounder Ben Horowitz, and Oprah Winfrey for a powerful conversation on resilience and transformation. Shaka, a resilience expert, motivational speaker, and bestselling author of Writing My Wrongs , shares his journey from incarceration to redemption along with insights from his new book, How to Be Free. Full of hard-earned wisdom and practical tools, it’s a guide for anyone seeking freedom in their own life....
Sep 05, 2025•37 min•Ep. 920
Is non-consensus investing overrated—or the secret to venture returns? a16z General Partner Erik Torenberg is joined by Martín Casado (General Partner, a16z) and Leo Polovets (General Partner, Humba Ventures) to unpack the debate that lit up venture Twitter/X: should founders and VCs chase consensus, or run from it? They explore what “consensus” really means in practice, how market efficiency shapes venture outcomes, why most companies fail from indigestion, not starvation, and the risks founder...
Sep 04, 2025•55 min•Ep. 917
Jack Altman sits down with Martin Casado, General Partner at a16z, to unpack the shifting dynamics of venture capital and why media matters more than ever. They cover a16z’s evolution from generalists to specialized platforms, the rise of AI infrastructure, and why today’s fiercest battles are often for talent, not market share. Timecodes: 0:00 Introduction 0:27 Importance of Media for VC 3:50 Evolution of a16z 7:00 Specialization 10:32 Value of Distribution 13:16 Staying Power in Infrastructure...
Sep 03, 2025•53 min•Ep. 918
What if the future of media isn’t controlled by algorithms or legacy institutions—but by independent voices building directly with their audiences? In this episode, Erik Torenberg is joined by Chris Best, cofounder and CEO of Substack, along with a16z general partners Katherine Boyle and Andrew Chen. We trace the origin story of Substack and its cultural impact, including how it reinvented the business model for independent media. We also explore the evolution of blogging, the rebundling of medi...
Sep 02, 2025•46 min•Ep. 915
Venture capital has powered companies like Facebook and TikTok—but what if that same urgency fueled America’s defense and industrial base? Katherine Boyle, General Partner at Andreessen Horowitz and cofounder of the firm’s American Dynamism practice, argues this is the biggest business opportunity of our time. In this conversation from The Shawn Ryan Show, Boyle discusses the rise of defense tech startups, why optimism drives her work, and how a new generation of engineers and founders is rethin...
Aug 30, 2025•2 hr 52 min•Ep. 914
In this interview from the 20VC podcast, Martin Casado (a16z General Partner) joins Harry Stebbings to unpack the state of AI, the rise of coding models, the future of open vs. closed source, and how value is shifting across the stack. Martin offers a candid view of the opportunities and dangers shaping AI and venture capital today. Resources: Find Martin on X: https://x.com/martin_casado Find Harry on X: https://x.com/harrystebbings More about 20VC: Subscribe on YouTube: https://www.youtube.com...
Aug 28, 2025•1 hr 17 min•Ep. 913
What are real consumers actually doing with AI today? In this episode, a16z consumer investors Olivia Moore and Justine Moore break down the fifth edition of our Consumer AI 100, a biannual ranking of the most used AI-native web and mobile products across the globe. Timecodes: 0:00 Introduction 1:45 New Companies & Trends 3:32 Companionship & Creative Tools 4:20 Big Tech on the List: Google’s Impact 6:24 Chinese AI Companies & Global Trends 10:19 Vibecoding: A New Trend 13:40 AI All-...
Aug 27, 2025•26 min•Ep. 912
What exactly is an AI agent, and how will agents change the way we work? In this episode, a16z general partners Erik Torenberg and Martin Casado sit down with Aaron Levie (CEO, Box) and Steven Sinofsky (a16z board partner; former Microsoft exec) to unpack one of the hottest debates in AI right now. They cover: Competing definitions of an “agent,” from background tasks to autonomous interns Why today’s agents look less like a single AGI and more like networks of specialized sub-agents The technic...
Aug 25, 2025•56 min•Ep. 911
Erik Torenberg sits down with Ben Horowitz, Cofounder of a16z, for a candid conversation on venture capital, leadership, and the future of innovation. Recorded live at a16z’s Menlo Park offices in 2023, Ben shares practical wisdom and hard-earned lessons on navigating market cycles, building resilient companies, and why culture is a lasting competitive edge. Timecodes: 0:00 Introduction 0:49 Building a Lasting Venture Firm 1:57 Product vs. Investor-Driven Firms 5:17 Evolution of Andreessen Horow...
Aug 23, 2025•44 min•Ep. 910
Marc Andreessen, cofounder Andreessen Horowitz, joins the Hermitix podcast for a conversation on AI, accelerationism, energy, and the future. From the thermodynamic roots of effective accelerationism (E/acc) to the cultural cycles of optimism and fear around new technologies, Marc shares why AI is best understood as code, how nuclear debates mirror today’s AI concerns, and what these shifts mean for society and progress. Timecodes: 0:00 Introduction 0:51 Podcast Overview & Guest Introduction...
Aug 22, 2025•1 hr 9 min•Ep. 909
Housing and healthcare make up nearly half of household spending, yet both sectors are riddled with inefficiency and rising costs. In this episode, Erik Torenberg is joined by a16z Growth partner Alex Immerman and Minna Song and Tony Stoyanov, cofounders of EliseAI, to discuss why they’re tackling these critical industries and how AI can transform everything from leasing and maintenance to patient scheduling and compliance. The conversation covers: Why the U.S. is 5 million housing units short —...
Aug 21, 2025•39 min•Ep. 908
Do tariffs help rebuild American manufacturing or hold it back? In this episode, American Compass founder and chief economist Oren Cass sits down with commentator and author Noah Smith and a16z General Partner Erik Torenberg for a lively debate on the future of U.S. industry. They discuss the case for tariff-driven re-industrialization versus free-market approaches, the role of allies in trade policy, and what the numbers really show about manufacturing jobs, investment, and output. Along the wa...
Aug 20, 2025•1 hr 13 min•Ep. 907
The AI hardware race is heating up, and NVIDIA is still far ahead. What will it take to close the gap? In this episode, Dylan Patel (Founder & CEO, SemiAnalysis) joins Erin Price-Wright (General Partner, a16z), Guido Appenzeller (Partner, a16z), and host Erik Torenberg to break down the state of AI chips, data centers, and infrastructure strategy. We discuss: Why simply copying NVIDIA won’t work, and what it takes to beat them How custom silicon from Google, Amazon, and Meta could reshape th...
Aug 18, 2025•1 hr 5 min•Ep. 906
Genie 3 can generate fully interactive, persistent worlds from just text, in real time. In this episode, Google DeepMind’s Jack Parker-Holder (Research Scientist) and Shlomi Fruchter (Research Director) join Anjney Midha, Marco Mascorro, and Justine Moore of a16z, with host Erik Torenberg, to discuss how they built it, the breakthrough “special memory” feature, and the future of AI-powered gaming, robotics, and world models. They share: How Genie 3 generates interactive environments in real time...
Aug 16, 2025•41 min•Ep. 905
a16z General Partners Martin Casado and Anjney Midha join Erik Torenberg to unpack one of the most dramatic shifts in tech policy in recent memory: the move from “pause AI” to “win the AI race.” They trace the evolution of U.S. AI policy—from executive orders that chilled innovation, to the recent AI Action Plan that puts scientific progress and open source at the center. The discussion covers how technologists were caught off guard, why open source was wrongly equated to nuclear risk, and what ...
Aug 15, 2025•42 min•Ep. 904
We’re sharing an episode from ChinaTalk that dives into one of the biggest recent reversals in U.S. tech policy. The U.S. banned Nvidia’s H20 AI chips to China in April. Now, just months later, they’re being sold—with a 15% export fee. What happened? Why the reversal? And what does it mean for the future of AI competition between the U.S. and China? Chris Miller—author of Chip War—and Lennart Heim from RAND join ChinaTalk host Jordan Schneider to unpack the policy flip-flop, why China is publicl...
Aug 14, 2025•1 hr 7 min•Ep. 903
a16z partners Olivia and Justine Moore unpack the latest in consumer AI including: - Grok’s “Imagine” and its instant, social-first creative tools - Google’s Genie 3 and the future of 3D worlds - GPT-5: what’s new, what’s missing, and why some want their old chatbot back - AI-generated music from ElevenLabs - Olivia’s vibecoded Jensen Huang selfie app Timecodes: 0:00 Introduction & This Week's Topics 0:24 Grok Imagine: Social AI Image & Video Generation 4:48 GPT-5 Release & GPT-4 Dep...
Aug 13, 2025•28 min•Ep. 902
Fresh off the announcement of his move from Shopify to a16z, Alex Danco joins TBPN to talk about the “trade deal” that brought him here and his mission to make the firm’s written content truly world class. He discusses why he believes writing still matters in the age of AI, how great prose can act as “power transfer technology” for founders, and why he’s betting on the overlooked art of speechwriting. Alex also reflects on his years as a founder, investor, and longtime blogger, and shares the fo...
Aug 13, 2025•15 min•Ep. 901
There’s been a wave of M&A deals lately - Meta and Scale, Windsurf and Google - and a lot of it points to something bigger: how regulation, capital, and innovation are colliding in 2025. In this episode Erik Torenberg brings together Steven Sinofsky, former Microsoft Executive and Balaji Srinivasan, founder of the Network School, and author of the Network State to break it all down. From acquihires to “acquifires,” from FTC crackdowns to the deeper battle between the state and the network, t...
Aug 11, 2025•1 hr 17 min•Ep. 900
In this episode, Marc Andreessen joins TBPN for an unfiltered conversation spanning everything from ads in LLMs to why Apple’s AI strategy may be risky for anyone not named Apple. Marc breaks down the current state of AI: why open source is resurging, how foundational research is (or isn’t) turning into product, and whether we’ve hit the moment when phones start to fade as dominant platforms. He also shares his candid thoughts on Meta’s wearable wins, Vision Pro’s imperfections, and how humor an...
Aug 08, 2025•37 min•Ep. 899
ChatGPT-5 just launched, marking a major milestone for OpenAI and the entire AI ecosystem. Fresh off the live stream, Erik Torenberg was joined in the studio by three people who played key roles in making this model a reality: Christina Kim, Researcher at OpenAI, who leads the core models team on post-training Isa Fulford, Researcher at OpenAI, who leads deep research and the ChatGPT agent team on post-training Sarah Wang, General Partner at a16z, who helped lead our investment in OpenAI since 2...
Aug 08, 2025•44 min•Ep. 898
