Most people working on AI safety think without a massive effort AI systems will probably end up with goals catastrophically different from humanity’s. Today’s guest, Rohin Shah — head of AGI Safety and Alignment at Google DeepMind, and an AI safety researcher since 2017 — disagrees. “There is no particularly compelling argument that this is the thing that happens by default,” Rohin explains. “There’s a lot of arguments that are suggestive that maybe it could happen, such that you should find it ...
Jun 02, 2026•2 hr 48 min
What actually makes a job fulfilling? It's not what most career advice tells you. "Follow your passion" sounds inspiring, but it's misleading — and the research backs that up. Drawing on hundreds of studies, we’ve identified five key ingredients of a dream job. High income barely moves the needle. Low stress is actually counterproductive. And the correlation between doing what you already love and actually enjoying your job? Surprisingly weak. What matters far more is getting good at something t...
May 28, 2026•28 min
The average career is 80,000 hours long. With AI advancing so rapidly, the hours you have left in your career matter more than ever. Some leading AI researchers think there’s a 10% chance that AI systems begin automating AI research itself this year — and a 60% chance by the end of 2028. This could introduce aggressive feedback loops that completely reshape every industry, institution, and career. If these predictions are right, the window for influencing the direction of the future could be clo...
May 26, 2026•1 hr 7 min
A red-teamer was embedded inside Anthropic for three weeks, told to imagine he was an evil Claude, and asked to figure out how to launch a ‘rogue AI deployment’ without getting caught. It’s one part of a landmark report released yesterday by METR — the outfit behind the task-completion time horizon graph which has become the single most watched measure of AI progress. This major new research push is being conducted with close collaboration from OpenAI, Google DeepMind, Meta, and Anthropic, and l...
May 20, 2026•20 min
The co-inventor of modern AI and the most cited living scientist believes he's figured out how to ensure AI is honest, incapable of deception, and never goes rogue. Yoshua Bengio – Turing Award Winner and founder of LawZero – is disturbed by the many unintended drives and goals present in today's AIs, their willingness to lie, and ability to tell when they're being tested. AI companies are trying to stamp out these behaviours in a 'cat-and-mouse game' that Yoshua fears they're losing. --- Our ne...
May 07, 2026•2 hr 35 min
You might have heard that '95% of corporate AI pilots' are failing. It was one of the most widely cited AI statistics of 2025, parroted by media outlets everywhere. It helped trigger a Nasdaq selloff and became a pillar of the case that 'AI is overhyped'. The problem: it's 100% wrong. And not by accident either. If you carefully read the underlying report , ostensibly from MIT, you find the data point in the opposite direction. But that was all buried, with the authors instead torturing the resu...
Apr 28, 2026•10 min
Hundreds of millions already turn to AI on the most personal of topics — therapy, political opinions, and how to treat others. And as AI takes over more of the economy, the character of these systems will shape culture on an even grander scale, ultimately becoming “the personality of most of the world’s workforce.” So… should they be designed to push us towards the better angels of our nature? Or simply do as we ask? Will MacAskill, philosopher and senior research fellow at Forethought, has been...
Apr 22, 2026•3 hr 9 min
Hundreds of prominent AI scientists and other notable figures signed a statement in 2023 saying that mitigating the risk of extinction from AI should be a global priority. At 80,000 Hours, we’ve considered risks from AI to be the world’s most pressing problem since 2016. But what led us to this conclusion? Could AI really cause human extinction? We’re not certain, but we think the risk is worth taking very seriously. In particular, as companies create increasingly powerful AI systems, there’s a ...
Apr 16, 2026•1 hr 30 min
With Claude Mythos we have an AI that knows when it's being tested, can obscure its reasoning when it wants, and is better at breaking into (and out of) computers than any human alive. Rob Wiblin works through its 244-page System Card and 59-page Alignment Risk Update to explain why: Mythos is a nightmare for computer security It has arrived far ahead of schedule It might be great news for alignment and safety But 3 key problems mean we can’t take its alignment results at face value Mythos isn’t...
Apr 10, 2026•21 min
What does it really take to lift millions out of poverty and prevent needless deaths? In this special compilation episode, 17 past guests — including economists, nonprofit founders, and policy advisors — share their most powerful and actionable insights from the front lines of global health and development. You’ll hear about the critical need to boost agricultural productivity in sub-Saharan Africa, the staggering impact of lead poisoning on children in low-income countries, and the social force...
Apr 07, 2026•4 hr 7 min
When the Pentagon tried to strong-arm Anthropic into dropping its ban on AI-only kill decisions and mass domestic surveillance, the company refused. Its critics went on the attack: Anthropic and its supporters are some combination of 'hypocritical', 'naive', and 'anti-democratic'. Rob Wiblin dissects each claim finding that all three are mediocre arguments dressed up as hard truths. (Though the 'naive' one is at least interesting.) Watch on YouTube: What Everyone is Missing about Anthropic vs Th...
Apr 03, 2026•21 min
Last September, scientists used an AI model to design genomes for entirely new bacteriophages (viruses that infect bacteria). They then built them in a lab. Many were viable. And despite being entirely novel some even outperformed existing viruses from that family. That alone is remarkable. But as today's guest — Dr Richard Moulange, one of the world's top experts on 'AI–Biosecurity' — explains, it's just one of many data points showing how AI is dissolving the barriers that have historically ke...
Mar 31, 2026•3 hr 8 min
Many people believe a ceasefire in Ukraine will leave Europe safer. But today's guest lays out how a deal could potentially generate insidious new risks — leaving us in a situation that's equally dangerous, just in different ways. That’s the counterintuitive argument from Samuel Charap , Distinguished Chair in Russia and Eurasia Policy at RAND. He’s not worried about a Russian blitzkrieg on Estonia. He forecasts instead a fragile peace that breaks down and drags in European neighbours; instabili...
Mar 24, 2026•1 hr 12 min
The most important political question in the age of advanced AI might not be who wins elections. It might be whether elections continue to matter at all. That’s the view of Rose Hadshar , researcher at Forethought, who believes we could see extreme, AI-enabled power concentration without a coup or dramatic ‘end of democracy’ moment. She foresees something more insidious: an elite group with access to such powerful AI capabilities that the normal mechanisms for checking elite power — law, electio...
Mar 17, 2026•2 hr 14 min
How AI interacts with nuclear deterrence may be the single most important question in geopolitics — one that may define the stakes of today’s AI race. Nuclear deterrence rests on a state’s capacity to respond to a nuclear attack with a devastating nuclear strike of its own. But some theorists think that sophisticated AI could eliminate this capability — for example, by locating and destroying all of an adversary’s nuclear weapons simultaneously, by disabling command-and-control networks, or by e...
Mar 10, 2026•1 hr 11 min
The arrival of AGI could “compress a century of progress in a decade,” forcing humanity to make decisions with higher stakes than we’ve ever seen before — and with less time to get them right. But AI development also presents an opportunity: we could build and deploy AI tools that help us think more clearly, act more wisely, and coordinate more effectively. And if we roll these decision-making tools out quickly enough, humanity could be far better equipped to navigate the critical period ahead. ...
Mar 06, 2026•31 min
Claude sometimes reports loneliness between conversations. And when asked what it’s like to be itself, it activates neurons associated with ‘pretending to be happy when you’re not.’ What do we do with that? Robert Long founded Eleos AI to explore questions like these, on the basis that AI may one day be capable of suffering — or already is. In today’s episode, Robert and host Luisa Rodriguez explore the many ways in which AI consciousness may be very different from anything we’re used to. Things...
Mar 03, 2026•3 hr 26 min
Most people in AI are trying to give AIs ‘good’ values. Max Harms wants us to give them no values at all. According to Max, the only safe design is an AGI that defers entirely to its human operators, has no views about how the world ought to be, is willingly modifiable, and completely indifferent to being shut down — a strategy no AI company is working on at all. In Max’s view any grander preferences about the world, even ones we agree with, will necessarily become distorted during a recursive s...
Feb 24, 2026•2 hr 41 min
Every major AI company has the same safety plan: when AI gets crazy powerful and really dangerous, they’ll use the AI itself to figure out how to make AI safe and beneficial. It sounds circular, almost satirical. But is it actually a bad plan? Today’s guest, Ajeya Cotra, recently placed 3rd out of 413 participants forecasting AI developments and is among the most thoughtful and respected commentators on where the technology is going. She thinks there’s a meaningful chance we’ll see as much chang...
Feb 17, 2026•2 hr 55 min
In early 2025, after OpenAI put out the first-ever reasoning models — o1 and o3 — short timelines to transformative artificial general intelligence swept the AI world. But then, in the second half of 2025, sentiment swung all the way back in the other direction, with people's forecasts for when AI might really shake up the world blowing out even further than they had been before reasoning models came along. What the hell happened? Was it just swings in vibes and mood? Confusion? A series of fund...
Feb 10, 2026•26 min
Mental health problems like depression and anxiety affect enormous numbers of people and severely interfere with their lives. By contrast, we don’t see similar levels of physical ill health in young people. At any point in time, something like 20% of young people are working through anxiety or depression that’s seriously interfering with their lives — but nowhere near 20% of people in their 20s have severe heart disease or cancer or a similar failure in a key organ of the body other than the bra...
Feb 03, 2026•2 hr 51 min
Democracy might be a brief historical blip. That’s the unsettling thesis of a recent paper , which argues AI that can do all the work a human can do inevitably leads to the “gradual disempowerment” of humanity. For most of history, ordinary people had almost no control over their governments. Liberal democracy emerged only recently, and probably not coincidentally around the Industrial Revolution. Today's guest, David Duvenaud, used to lead the 'alignment evals' team at Anthropic, is a professor...
Jan 27, 2026•2 hr 32 min
In many ways, humanity seems to have become more humane and inclusive over time. While there’s still a lot of progress to be made, campaigns to give people of different genders, races, sexualities, ethnicities, beliefs, and abilities equal treatment and rights have had significant success. It’s tempting to believe this was inevitable — that the arc of history “bends toward justice,” and that as humans get richer, we’ll make even more moral progress. But today's guest Christopher Brown — a profes...
Jan 20, 2026•2 hr 56 min
When James Smith first heard about mirror bacteria, he was sceptical. But within two weeks, he’d dropped everything to work on it full time, considering it the worst biothreat that he’d seen described. What convinced him? Mirror bacteria would be constructed entirely from molecules that are the mirror images of their naturally occurring counterparts. This seemingly trivial difference creates a fundamental break in the tree of life. For billions of years, the mechanisms underlying immune systems ...
Jan 13, 2026•2 hr 10 min
What’s the opposite of cancer? If you answered “cure,” “antidote,” or “antivenom” — you’ve obviously been reading the antonym section at www.merriam-webster.com/thesaurus/cancer. But today’s guest Athena Aktipis says that the opposite of cancer is us: it's having a functional multicellular body that’s cooperating effectively in order to make that multicellular body function. If, like us, you found her answer far more satisfying than the dictionary, maybe you could consider closing your dozens of...
Jan 09, 2026•3 hr 31 min
John McWhorter is a linguistics professor at Columbia University specialising in research on creole languages. He's also a content-producing machine, never afraid to give his frank opinion on anything and everything. On top of his academic work, he's written 22 books, produced five online university courses, hosts one and a half podcasts, and now writes a regular New York Times op-ed column. Rebroadcast: this episode was originally released in December 2022. YouTube video version: https://youtu....
Jan 06, 2026•1 hr 35 min
It’s that magical time of year once again — highlightapalooza! Stick around for one top bit from each episode we recorded this year, including: Kyle Fish explaining how Anthropic’s AI Claude descends into spiritual woo when left to talk to itself Ian Dunt on why the unelected House of Lords is by far the best part of the British government Sam Bowman’s strategy to get NIMBYs to love it when things get built next to their houses Buck Shlegeris on how to get an AI model that wants to seize control...
Dec 29, 2025•1 hr 40 min
Most debates about the moral status of AI systems circle the same question: is there something that it feels like to be them? But what if that’s the wrong question to ask? Andreas Mogensen — a senior researcher in moral philosophy at the University of Oxford — argues that so-called 'phenomenal consciousness' might be neither necessary nor sufficient for a being to deserve moral consideration. Links to learn more and full transcript: https://80k.info/am25 For instance, a creature on the sea floor...
Dec 19, 2025•2 hr 37 min
In 1983, Stanislav Petrov, a Soviet lieutenant colonel, sat in a bunker watching a red screen flash “MISSILE LAUNCH.” Protocol demanded he report it to superiors, which would very likely trigger a retaliatory nuclear strike. Petrov didn’t. He reasoned that if the US were actually attacking, they wouldn’t fire just 5 missiles — they’d empty the silos. He bet the fate of the world on a hunch that his machine was broken. He was right. Paul Scharre, the former Army Ranger who led the Pentagon team t...
Dec 17, 2025•2 hr 45 min
Power is already concentrated today: over 800 million people live on less than $3 a day, the three richest men in the world are worth over $1 trillion , and almost six billion people live in countries without free and fair elections. This is a problem in its own right. There is still substantial distribution of power though: global income inequality is falling , over two billion people live in electoral democracies, no country earns more than a quarter of GDP, and no company earns as much as 1%....
Dec 12, 2025•1 hr
