TWiP explains how circadian clocks of parasite and vector circadian mediate efficient malaria transmission. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Clocks mediate malaria transmission (Nat Micro) Hero: Dame Bridget Ogilvie ( Wiki ) Become a patron of TWiP Send your questions and comments to [email protected] Music by Ronald Jenkees...
Jun 24, 2025•1 hr 6 min•Ep. 260
TWiP solves the case of the man in the Malaysian city of Kucheng who presents with daily fevers and shaking chills, and serve a new clinical puzzle for you to solve. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 259 New Case Another case from Northern Tanzania, up by the border of Kenya. 32 yo pregnant woman admitted to the hospital, de...
Jun 02, 2025•57 min•Ep. 259
TWiP describes how a gut commensal protozoan influences respiratory disease outcomes by shaping pulmonary immunity, and body shape variation in lice that parasitize diving hosts. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Gut commensal shapes pulmonary immunity (Cell) The deeper the rounder (Sci Rep) Become a patron of TWiP Send your questions and commen...
May 13, 2025•1 hr 3 min•Ep. 258
TWiP solves the case of the man in the Malaysian city of Kucheng who presents with left arm swelling, and presents a new case for you to decipher. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 257 New Case We are still in Kuching, Malaysia in the northern part of the Island of Borneo. This is the Sarawak portion of Malaysia. A man in hi...
Apr 20, 2025•51 min•Ep. 257
TWiP explains a study that carries out selection of Plasmodium falciparum in the presence of inhibitors to identify determinants of drug resistance, and a paleoparasitological analysis of a 5th–16th c. CE latrine. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Naegleria fowleri acquired at splash pad (MMWR) Determinants of P. falciparum drug resistance (Scie...
Apr 04, 2025•1 hr 3 min•Ep. 256
Michelle Labrunda joins TWiP to solve the case of the Georgian in Guinea with fever and dry cough, and describe a new case for you to solve. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Guest: Michelle Labrunda Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 255 New Case A man who is on eculizumab, a recombinant humanized monoclonal antibody that targets complement protein C5 which ...
Mar 22, 2025•57 min•Ep. 255
TWiP explains a study which finds that tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei, then remembers our departed colleague Dickson Despommier. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Click arrow to play Download TWiP #254 (88 MB .mp3, 61 minutes) Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Tissue spaces are reservoirs of antigenic diversity for T. brucei (Nature) U...
Mar 09, 2025•1 hr 1 min•Ep. 254
TWiP solves the case of the man with somnolence and something extra-erythrocytic, and presents a new puzzle for you to solve. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 253 New Case 26-year-old female with no past medical history. Patient is from Georgia in the US and is volunteering in Hérico, Guinea (town in the Lélouma Prefecture ...
Feb 22, 2025•1 hr 2 min•Ep. 253
TWiP discusses a study of the safety and immunogenicity of a late liver-stage attenuated malaria parasite delivered by mosquito bite. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Live attenuated malaria vaccine (NEJM) Plasmodium metabolism during hepatic development (Cell) Heroes – Jimmy and Rosallyn Carter , and the Carter Center The Carter Center Guinea ...
Feb 10, 2025•54 min•Ep. 252
TWiP solves the case of the woman who went to Belize and notices a lesion on her face, and presents a new clinical case for you to solve. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 251 New Case Recent case, Arusha hospital, 1800 m, 28 yo comes in, has been visiting game parks. Developing fevers, malaise, bad headaches, body aches, so...
Jan 17, 2025•57 min•Ep. 251
TWiP reviews a study showing that the gut microbiota is essential for suppression of colitis by Trichinella spiralis . Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Gut bacteria and Trichinella suppression of colitis (PLoS NTD) Become a patron of TWiP Send your questions and comments to [email protected] Music by Ronald Jenkees...
Jan 03, 2025•52 min•Ep. 250
TWiP solves the case of the middle-aged man with eosinophilia and a history of sexual activity with paid sex workers in Okinawa, and presents a new case for you to solve. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 249 New Case Woman in 30s or 40s goes to Belize and after returning notices a lesion on her face. She goes to see several...
Dec 20, 2024•56 min•Ep. 249
TWiP reviews the observation that infection of Azlheimer’s disease mice with Toxoplasma gondii reduces brain amyloid density globally and regionally. Hosts: Vincent Racaniello , Dickson Despommier , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Toxoplasma reduces amyloid in brain (J Inf Dis) Hero: Theodor Hiepe (Parasitol Res) Become a patron of TWiP Send your questions and comments t...
Dec 06, 2024•1 hr 7 min•Ep. 248
TWiP solves the case of the Manhattan man with pain on urination or ejaculation, and presents a new case for you to solve. Hosts: Vincent Racaniello , Dickson Despommier , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Hero: Charles Louis Alphonse Laveran Letters read on TWiP 247 New Case A middle-aged male is referred to evaluation because of eosinophilia. This man is married, living ...
Nov 18, 2024•58 min•Ep. 247
TWiP taps into Dickson’s knowledge of Trichinella to discuss an outbreak in humans who consumed rare bear meat, and the impact of globalization and climate change on the epidemiology of the species. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Outbreak of human trichinellosis (CCDR) Impact of climate change on Trichinella (Food Waterborne Parasit) Lette...
Nov 01, 2024•1 hr 24 min•Ep. 246
Founder of Floating Doctors Ben LaBrot joins TWiP to solve the case of the 1 year old in northeastern Panama with a fatal leg infection, followed by a discussion of the history and mission of Floating Doctors. Hosts: Vincent Racaniello , Daniel Griffin , and Christina Naula Guest: Ben LaBrot Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Floating Doctors Letters read on TWiP 245 New Case A man in his early 20s comes in re...
Oct 18, 2024•1 hr 16 min•Ep. 245
Lilach Sheiner joins TWiP to talk about her career and her work on engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons. Hosts: Vincent Racaniello , Dickson Despommier , and Christina Naula Guest: Lilach Sheiner Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Engineering T. gondii for protein secretion (Nat Micro) Become a patron of TWiP Send your ques...
Oct 05, 2024•50 min•Ep. 244
TWiP solves the case of the Woman with White Worms, and submits a new case involving a 1 year old in northeastern Panama with a fatal leg infection. Hosts: Vincent Racaniello , Dickson Despommier , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Enterobius, the pinworm ( TWiP 19 ) Hero: Mary Pritchard New Case This case comes from Panama mid summer 2024. A provider for Floating Doctors ...
Sep 20, 2024•1 hr 6 min•Ep. 243
TWiP reviews a study showing that intestinal helminth infection impairs vaccine-induced T cell responses through an IL-10 pathway, which compromised protection against antigenically drifted SARS-CoV-2 variants. Hosts: Vincent Racaniello , Daniel Griffin and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Worms impair COVID vaccines (Sci Trans Med) Heligmosomoides image (Wiki Commons) Become a patron of TWiP...
Sep 06, 2024•48 min•Ep. 242
Aug 19, 2024•1 hr 15 min•Ep. 241
Sean Murphy joins TWiP to discuss his career and the work of his laboratory to assess the daily natural history of asymptomatic Plasmodium infections in adults and older children in Katakwi, Uganda. Hosts: Vincent Racaniello , Dickson Despommier and Christina Naula Guest: Sean Murphy Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Daily natural history of Plasmodium infections (Lancet Microbe) Become a patron of TWiP Send ...
Aug 02, 2024•57 min•Ep. 240
TWiP solves the case of the AIDS patient who developed fever and watery diarrhea after drinking NYC tap water, and present a new case for your sleuthing. Hosts: Vincent Racaniello and Daniel Griffin Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Cryptosporidium ( TWiP 18 ) Letters read on TWiP 239 Become a patron of TWiP New Case Man in his 70s originally from Mainland China, then Hong Kong who has been living in the US f...
Jul 19, 2024•31 min•Ep. 239
Michael Barrett joins TWiP to discuss progress in the elimination of human African trypanosomiasis caused by Trypanosoma brucei gambiense . Hosts: Daniel Griffin , Dickson Despommier and Christina Naula Guest: Michael Barrett Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Elimination of human African trypanosomiasis (PLoS NTD) Hero: David Livingstone Become a patron of TWiP Send your guesses to [email protected] with TWiP 2...
Jul 05, 2024•1 hr 37 min•Ep. 238
Marilyn Fabbri joins TWiP to reveal the case of a patient who became very ill after he and a number of friends attended a large dinner where venison and boar were served. Hosts: Daniel Griffin , Dickson Despommier and Christina Naula Guest: Marilyn Fabbri Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Toxoplasma gondii ( TWiP 12 ) Parasitic Diseases Lectures #15: Toxoplasmosis Letters read on TWiP 237 Become a patron of T...
Jun 21, 2024•57 min•Ep. 237
Marion Avril of MalarVx, Inc. joins TWiP to discuss an accelerated prime-and-trap regimen using repRNA-based circumsporozoite vaccine. Hosts: Dickson Despommier and Christina Naula Guest: Marion Avril Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Please support our work at microbe.tv/contribute repRNA-based CSP malaria vaccine (NPJ vaccines) Hero: Mwelecele Ntuli Malecela Become a patron of TWiP Send your guesses to twip...
Jun 01, 2024•1 hr 13 min•Ep. 236
TWiP solves the case of a man in his 50s reporting months of abdominal discomfort, who takes mebendazole and some time afterwards vomits a worm into the sink. Hosts: Vincent Racaniello , Dickson Despommier , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Please support our work at microbe.tv/contribute The giant intestinal worm, Ascaris lumbricoides ( TWiP 21 ) Parasitic Diseases Lectu...
May 17, 2024•1 hr 16 min•Ep. 235
TWiP discusses hookworm infection and the phase 1 clinical trial for a hookworm vaccine that could one day protect children from the hookworm anaemia, and reduce transmission of this infection. Hosts: Dickson Despommier , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Please support our work at microbe.tv/contribute Hookworm vaccines in school-aged children in Gabon (Lancet Inf Dis) St...
May 04, 2024•1 hr 23 min•Ep. 234
TWiP solves the case of the physician with no significant previous medical history who is currently doing their fellowship training develops diarrhea, and presents a new clinical case for our astute listeners to solve. Hosts: Vincent Racaniello , Dickson Despommier , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Please support our work at microbe.tv/contribute Hero: Keith Vickerman Le...
Apr 19, 2024•1 hr 21 min•Ep. 233
TWiP reviews the cellular lives of Wolbachia, a gram-negative bacteria that infects many arthropods and filarial nematodes with very different outcomes – parasitism or mutualism. Hosts: Dickson Despommier , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Please support our work at microbe.tv/contribute Cellular lives of Wolbachia (Nat Rev Micro) Hero: Patricia F. Walker Become a patron ...
Apr 05, 2024•54 min•Ep. 232
TWiP solves the case of the Woman With White Worms, and presents a new clinical case to decipher. Hosts: Vincent Racaniello , Dickson Despommier , Daniel Griffin , and Christina Naula Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Links for this episode Join the MicrobeTV Discord server Please support our work at microbe.tv/contribute Hero: Ann Bishop Become a patron of TWiP New Case study: A physician with no significant PMH who is currently doing their fellowship training dev...
Mar 31, 2024•56 min•Ep. 231
